CALL FOR PAPERS Novel Therapeutics In Renal Disease Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels
نویسندگان
چکیده
Matthew Tan, Hiromi I. Wettersten, Kristy Chu, David L. Huso, Terry Watnick, Sharon Friedlander, Yosef Landesman, and Robert H. Weiss Graduate Group in Comparative Pathology, Division of Nephrology, Department of Internal Medicine, and Cancer Center, University of California, Davis, California; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland; Karyopharm Therapeutics, Inc., Natick, Massachusetts; and Medical Service, Sacramento Veterans Affairs Medical Center, Sacramento, California
منابع مشابه
Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive, proliferative renal disease. Kidneys from ADPKD patients are characterized by the presence of cysts that are marked by enhanced proliferation and apoptosis of renal tubular epithelial cells. Current treatment of this disease is supportive, as there are few if any clinically validated targeted therapeutics. Given the parallel...
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